With such a long journey, we would like to give you some advice: you can look for a flight to Brussels, or if your budget is limited, you can check night buses and trains to save the daytime for your visits.
Travelling by bus to Brussels from Rome: how many daily connections are there?
When are the buses of the line Rome - Brussels scheduled?
The earliest time you can leave from Rome is at 12:10, while the last bus is at 20:10. The journey takes on average 29 hours and 12 minutes but it can also last 24 hours and 15 minutes with the fastest connections.
Which companies can you travel with from Rome to Brussels?
There are many companies cooperating with virail, among which also FlixBus, Eurolines SA and Eurolines with buses to Brussels.
Flixbus is undoubtedly one of the youngest and most famous bus companies in whole Europe. With more than 40 millions passengers only in 2017, Flixbus offers national and international bus connections, also with night buses.
Eurolines is one of the leader bus companies in Europe, with more than 350 connections in 23 countries. Among its services you can also find long-distance night buses.